Holberton School ยท 9-Month CS Program Archive

CS Foundations for
Computational Biology

A complete archive of low-level systems programming, algorithms, full-stack architectures, and DevOps coursework โ€” providing the engineering backbone for modern bioinformatics.

๐Ÿ›๏ธ View Organization Explore Modules โ†“
9
Months Intensive Study
16+
Coursework Modules
5+
Core Languages
3
Specialization Pillars

๐Ÿ—‚๏ธ Curriculum Modules

All coursework modules completed during the intensive program

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Low-Level Programming & C

Memory layout, pointer arithmetic, dynamic allocation, structures, bit manipulation, and system calls.

C ยท Valgrind
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Custom printf

From-scratch implementation of the standard C printf with specifiers (%d, %s, %c, %x, %p) and buffer handling.

C
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Binary Trees & Sorting

Binary Search Trees, AVL balance rotations, traversals (pre/in/post-order), Quick sort, Merge sort, and Big-O efficiency.

C ยท Algorithms
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UNIX Shell Interpreter

Command line interpreter: process management with fork/execve, signal handling, paths, and builtins.

C ยท POSIX
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Higher-Level Python

Object-Oriented Programming (OOP), file serialization (JSON), unit testing (unittest), SQL ORM, and REST APIs.

Python ยท SQL
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AirBnB Clone (hbnb)

Full-stack project: CLI console interpreter, Flask web framework, MySQL database engine, and HTML/CSS presentation.

Python ยท Flask ยท MySQL
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DevOps & Docker

Automated deployment, configuration management, Nginx load balancers, SSL certificates, and Docker containerization.

Bash ยท Docker ยท Nginx
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Network Protocols

OSI 7 layers, TCP/IP, UDP sockets, DNS resolution, HTTP request/response lifecycles, and network security.

Networking ยท Bash
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Web Engineering

Responsive design, modern React hooks, Node.js server runtimes, Express routing, and MongoDB document databases.

React ยท Node.js ยท MongoDB

๐Ÿ”ฌ CS Foundations โ†’ Bioinformatics Bridge

How each computer science domain directly powers high-throughput bioinformatics & computational biology

๐Ÿง 

C Memory Management โ†’ Sequence Parsers

Direct pointer manipulation and heap optimization are required to build high-performance genomic aligners like BLAST, BWA, and Bowtie.

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Trees & Graph Algorithms โ†’ Phylogenetics

Tree traversals and shortest-path graph algorithms are the mathematical foundation of phylogenetic trees and de Bruijn genome assembly graphs.

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Docker & DevOps โ†’ Reproducible Workflows

Containerizing software environments guarantees 100% scientific reproducibility across HPC clusters, Nextflow, and Snakemake pipelines.

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Python OOP โ†’ Omics Tooling

Object-oriented abstractions allow structured handling of complex biological entities: gene features, FASTA records, and BAM alignments.

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REST APIs โ†’ Biological Databases

API client design enables programmatic access to NCBI E-utilities, Ensembl REST, UniProt, ClinVar, and AlphaFold databases.

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System Engineering โ†’ HPC Clusters

Linux administration, bash scripting, and process control are crucial for managing SLURM job arrays and high-throughput sequencing runs.

๐Ÿ‘จโ€๐Ÿ’ป About the Author

Bioinformatics Researcher & Computational Biologist

Suleiman Hajizadeh

Suleiman Hajizadeh

Bioinformatician & Computational Biologist

Equipped with a solid foundation from the intensive 9-month Holberton School Computer Science program, applying software engineering principles to computational biology, genomics, and multi-omics data analysis.